TLR7 Monoclonal Antibody - BT-MCA3182

TLR7 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3182-50, BT-MCA3182-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.

Research Areas: Others

Target Protein: TLR7

Applications: FCM

Clonality: Monoclonal

Clone ID: 3A9E11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TLR7

Immunogen: Purified recombinant fragment of human TLR7 (AA: 420-644) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 120kDa

UniProt Accession: Q9NYK1

Synonyms: IMD74, TLR7-like

GeneID: 51284

Research Use Only