TNF Alpha Monoclonal Antibody - BT-MCA1212

TNF Alpha Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1212-50, BT-MCA1212-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Research Areas: Signal transduction; Immunology; Microbiology; Cardiovascular; Cancer; Metabolism

Target Protein: TNF

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Tumor necrosis factor

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P01375; Mouse: P06804

Synonyms: TNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a

GeneID: Human: 7124

Research Use Only