TNF-alpha Monoclonal Antibody - BT-MCA3611

TNF-alpha Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3611-50, BT-MCA3611-100

Citations, Manuals and MSDS Available upon request.

Background: TNF-alpha (tumor necrosis factor alpha) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF-alpha exists as a multimer of two, three, or five non covalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF-alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF-alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Research Areas: Others

Target Protein: TNF-alpha

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2A9B9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TNF-alpha

Immunogen: Recombinant Human TNF-alpha (BioSource company, Cat.No. PHC3013)

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P01375

Synonyms: DIF, TNFA, TNFSF2, TNF-alpha

GeneID: 7124

Research Use Only