TNFSF9 Monoclonal Antibody - BT-MCA4048

TNFSF9 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4048-50, BT-MCA4048-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Research Areas: Immunology

Target Protein: TNFSF9

Applications: FCM

Clonality: Monoclonal

Clone ID: 2B7B8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TNFSF9

Immunogen: Purified recombinant fragment of human TNFSF9 (AA: Extra(50-254)) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 27kDa

UniProt Accession: P41273

Synonyms: CD137L, TNLG5A, 4-1BB-L

GeneID: 8744

Research Use Only