TNK1 Monoclonal Antibody - BT-MCA1213

TNK1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1213-50, BT-MCA1213-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Signal transduction

Target Protein: TNK1

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Non-receptor tyrosine-protein kinase TNK1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q13470; Mouse: Q99ML2

Synonyms: TNK1; Non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1

GeneID: Human: 8711

Research Use Only