TNK1 Monoclonal Antibody - BT-MCA2822

TNK1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2822-50, BT-MCA2822-100

Citations, Manuals and MSDS Available upon request.

Background: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Research Areas: Signal transduction

Target Protein: TNK1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1B5G3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TNK1

Immunogen: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q13470

Synonyms: MGC46193, TNK1

GeneID: 8711

Research Use Only