TNNI2 Monoclonal Antibody - BT-MCA4539

TNNI2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4539-50, BT-MCA4539-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Signal transduction

Target Protein: TNNI2

Applications: ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2F12G2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TNNI2

Immunogen: Purified recombinant fragment of human TNNI2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 21kDa

UniProt Accession: P48788

Synonyms: DA2B, FSSV, fsTnI, AMCD2B

GeneID: 7136

Research Use Only