Product Description

TNNI2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS71003-50, BS71003-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P48788

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB 1:500 - 1:1000

Background: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TNNI2 polyclonal antibody detects endogenous levels of TNNI2 protein.

Bioworld Molecular Weight: ~ 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TNNI2 polyclonal antibody at 1:500 dilution
Lane A: The skeletal muscle tissue lysate of Mouse(40ug)
Lane B: The skeletal muscle tissue lysate of Rat(40ug)

Alternative Name: DA2B; FSSV; fsTnI; AMCD2B

Immunogen: Synthetic peptide, corresponding to Human TNNI2.

Conjugate: Unconjugated

Modification: Unmodified