TOP1M Polyclonal Antibody - BT-AP15064

TOP1M Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15064-20, BT-AP15064-50, BT-AP15064-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Areas: Epigenetics and nuclear signaling

Target Protein: TOP1MT

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: DNA topoisomerase I, mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q969P6; Mouse: Q8R4U6; Rat: Q6IM78

Synonyms: DNA topoisomerase I, mitochondrial;TOP1mt;EC 5.99.1.2

GeneID: Human: 116447

Research Use Only