Topo I Polyclonal Antibody - BT-AP09127

Topo I Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09127-20, BT-AP09127-50, BT-AP09127-100

Citations, Manuals and MSDS Available upon request.

Background: TOP1 (topoisomerase (DNA) I) encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. TOP1 is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: TOP1

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Topo I Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 90726

UniProt Accession: Human: P11387; Mouse: Q04750; Rat: Q9WUL0

Synonyms: TOP1; DNA topoisomerase 1; DNA topoisomerase I

GeneID: Human: 7150; Mouse: 21969; Rat: 64550

Research Use Only