TORC1 Monoclonal Antibody - BT-MCA1215

TORC1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1215-50, BT-MCA1215-100

Citations, Manuals and MSDS Available upon request.

Background: A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11|19)(q21|p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.,function:Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.

Research Areas: Signal transduction; Metabolism; Epigenetics and nuclear signaling

Target Protein: CRTC1

Applications: WB, FCM, IF, ICC

Reactivity: Human,Mouse,Rat,Pig

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: CREB-regulated transcription coactivator 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q6UUV9; Mouse: Q68ED7; Rat: Q157S1

Synonyms: CRTC1; KIAA0616; MECT1; TORC1; WAMTP1; CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1

GeneID: Human: 23373; Mouse: 382056; Rat: 684527

Research Use Only