Product Description

TPH2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4690-50, ES4690-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TPH2, NTPH, Tryptophan 5-hydroxylase 2, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TPH2. AA range:4-53

Isotype: IgG

Target: TPH2

Specificity: TPH2 Polyclonal Antibody detects endogenous levels of TPH2 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain specific,

Observed Band (KD): 56kD

Fields: Tryptophan metabolism, Folate biosynthesis, Metabolic pathways, Serotonergic synapse

Function: Catalytic Activity: L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
Cofactor: Fe(2+) ion
Disease: Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM: 608516]
Pathway: Aromatic compound metabolism, serotonin biosynthesis, serotonin from L-tryptophan: step 1/2
Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family
Similarity: Contains 1 ACT domain
Tissue Specificity: Brain specific

Subcellular Location: cytosol, neuron projection,

Storage and Stability: -20°C/1 year

Gene Name: TPH2

Protein Name: Tryptophan 5-hydroxylase 2

Mouse Gene ID: 216343

Mouse SwissProt Number: Q8CGV2

Rat Gene ID: 317675

Rat SwissProt Number: Q8CGU9

Research Use Only