TPSAB1 Monoclonal Antibody - BT-MCA2470

TPSAB1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2470-50, BT-MCA2470-100

Citations, Manuals and MSDS Available upon request.

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Research Areas: Epigenetics and nuclear signaling, Developmental biology, Stem cells, Tags and cell markers

Target Protein: TPSAB1

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1B2E6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TPSAB1

Immunogen: Purified recombinant fragment of human TPSAB1 (AA: 31-275) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 30.5kDa

UniProt Accession: Q15661

Synonyms: TPS1, TPS2, TPSB1, TPSB2, Tryptase-2

GeneID: 7177

Research Use Only