Product Description

TRAIL Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4241-50, ES4241-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provi

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: TNFSF10, APO2L, TRAIL, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF10. AA range:31-80

Isotype: IgG

Target: TRAIL

Specificity: TRAIL Polyclonal Antibody detects endogenous levels of TRAIL protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widespread, most predominant in spleen, lung and prostate,

Observed Band (KD): 33kD

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, FoxO signaling pathway, Apoptosis, Necroptosis, Natural killer cell mediated cytotoxicity, Pathogenic Escherichia coli infection, Salmonella infection, Influenza A, Lipid and atherosclerosis

Function: Cofactor: Binds 1 zinc ion per trimer
Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis
Similarity: Belongs to the tumor necrosis factor family
Subunit: Homotrimer
Tissue Specificity: Widespread, most predominant in spleen, lung and prostate

Subcellular Location: Cell membrane, Single-pass type II membrane protein Secreted Exists both as membrane-bound and soluble form

Storage and Stability: -20°C/1 year

Gene Name: TNFSF10

Protein Name: Tumor necrosis factor ligand superfamily member 10

Mouse SwissProt Number: P50592

Research Use Only