TRIB2 Monoclonal Antibody - BT-MCA3027

TRIB2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3027-50, BT-MCA3027-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Research Areas: Signal transduction, Cancer, Stem cells, Cardiovascular

Target Protein: TRIB2

Applications: IHC, ICC, FCM

Clonality: Monoclonal

Clone ID: 6A12A12

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: TRIB2

Immunogen: Purified recombinant fragment of human TRIB2 (AA: 1-200) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 38.8kDa

UniProt Accession: Q92519

Synonyms: C5FW, TRB2, GS3955

GeneID: 28951

Research Use Only