Trim5a Monoclonal Antibody - BT-MCA4213

Trim5a Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4213-50, BT-MCA4213-100

Citations, Manuals and MSDS Available upon request.

Background: TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

Research Areas: Others

Target Protein: Trim5a

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3B11H2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: Trim5a

Immunogen: Purified recombinant fragment of human trim5 alpha expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q9C035

Synonyms: RNF88, TRIM5alpha

GeneID: 85363

Research Use Only