Troponin I-FS Monoclonal Antibody - BT-MCA1236

Troponin I-FS Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1236-50, BT-MCA1236-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced trans

Research Areas: Signal transduction

Target Protein: TNNI2

Applications: WB, IHC-p, IF, FCM, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Troponin I fast skeletal muscle

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P48788; Mouse: P13412

Synonyms: TNNI2; Troponin I; fast skeletal muscle; Troponin I; fast-twitch isoform

GeneID: Human: 7136

Research Use Only