TRXR1 Polyclonal Antibody - BT-AP15190

TRXR1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15190-20, BT-AP15190-50, BT-AP15190-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for Catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3andapos; UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

Research Areas: Signal transduction; Cell biology; Metabolism

Target Protein: TXNRD1

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Thioredoxin reductase 1, cytoplasmic

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q16881; Mouse: Q9JMH6; Rat: O89049

Synonyms: Thioredoxin reductase 1, cytoplasmic;TR;EC 1.8.1.9;Gene associated with retinoic and interferon-induced mortality 12 protein;GRIM-12;Gene associated with retinoic and IFN-induced mortality 12

GeneID: Human: 7296

Research Use Only