Tryptase-3 Polyclonal Antibody - BT-AP09251

Tryptase-3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09251-20, BT-AP09251-50, BT-AP09251-100

Citations, Manuals and MSDS Available upon request.

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3and#39; UTR and contain tandem repeat sequences at the 5and#39; flank and 3and#39; UTR which are thought to play a role in regulation of the mRNA stability. Although TPSD1 (tryptase delta 1) may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. TPSD1 was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.

Research Areas: Others

Target Protein: TPSD1

Applications: WB, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Tryptase-3 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 26584

UniProt Accession: Human: Q9BZJ3

Synonyms: Tryptase delta (EC 3.4.21.59) (Delta-tryptase) (HmMCP-3-like tryptase III; Mast cell mMCP-7-like Tryptase-3

GeneID: Human: 23430

Research Use Only