Product Description

TSC22 (E73) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2661-50, BS2661-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transforming growth factor-β-stimμlated clone-22 (TSC-22) acts as a transcriptionalregμlator to modμlate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resμlting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regμlatory activity. TSC-22 acts as a major downstream component in the TGF-β pathway, and also the PPARγ signalling pathway. The association of these two pathways with tumor suppression, and the significant downregμlation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: TSC22 domain family protein 1, Cerebral protein 2, Regμlatory protein TSC-22, TGFB-stimμlated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, TSC22D1, KIAA1994, TGFB1I4, TSC22, hucep-2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 41-93 of Human TSC22.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: TSC-22 (E73) polyclonal antibody detects endogenous levels of TSC-22 protein.

Molecular Weight: ~ 16 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15714

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only