Product Description

TTN Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35679-50, RA35679-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: titin (TTN) Homo sapiens This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC-p, IF (paraffin section), ELISA

Alternate Names: Titin (EC 2.7.11.1;Connectin;Rhabdomyosarcoma antigen MU-RMS-40.14)

Clonality: Polyclonal

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000

Storage: -20°C/1 year

Human Gene ID: 7273

Human SwissProt Number: Q8WZ42

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only