Tyk 2 Monoclonal Antibody - BT-MCA1259

Tyk 2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1259-50, BT-MCA1259-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Research Areas: Signal transduction; Cardiovascular; Immunology

Target Protein: TYK2

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Non-receptor tyrosine-protein kinase TYK2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P29597; Mouse: Q9R117

Synonyms: TYK2; Non-receptor tyrosine-protein kinase TYK2

GeneID: Human: 7297

Research Use Only