Tyk2 Monoclonal Antibody - BT-MCA2927

Tyk2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2927-50, BT-MCA2927-100

Citations, Manuals and MSDS Available upon request.

Background: Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

Research Areas: Signal Transduction

Target Protein: Tyk2

Reactivity: Human

Clonality: Monoclonal

Clone ID: 8G8B3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: Tyk2

Immunogen: Purified recombinant fragment of Tyk2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P29597

Synonyms: JTK1

GeneID: 7297

Research Use Only