Product Description

Tyk2 (phospho-Tyr1054/1055) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12474-50, ES12474-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Alternate Names: Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)

Isotype: IgG

Target: Tyk2,

Specificity: This antibody detects endogenous levels of Human Tyk2 (phospho-Tyr1054 or 1055)

Dilution: WB 1:1000-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

Observed Band (KD): 134kD

Fields: Necroptosis, Osteoclast differentiation, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19

Function: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Disease: Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. Domain: The FERM domain mediates interaction with JAKMIP1. Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. online information:TYK2 mutation db, Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Similarity: Contains 1 FERM domain. Similarity: Contains 1 protein kinase domain. Similarity: Conta

Subcellular Location: nucleus, cytoplasm, cytosol, cytoskeleton, membrane, extrinsic component of cytoplasmic side of plasma membrane, extracellular exosome,

Storage and Stability: -20°C/1 year

Gene Name: TYK2

Protein Name: Tyk2, Tyr1054/1055

Human Gene ID: 7297

Human SwissProt Number: P29597

Mouse SwissProt Number: Q9R117

Research Use Only