TYRO3 Monoclonal Antibody - BT-MCA2672

TYRO3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2672-50, BT-MCA2672-100

Citations, Manuals and MSDS Available upon request.

Background: TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky. Entrez Protein: NP_006284. It belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.

Research Areas: Signal transduction, Neuroscience

Target Protein: TYRO3

Reactivity: Human

Clonality: Monoclonal

Clone ID: 10E11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TYRO3

Immunogen: Purified recombinant extracellular fragment of human TYRO3 fused with hIgGFc tag expressed in HEK293 cell line.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 96.9kDa

UniProt Accession: Q06418

Synonyms: BYK, Brt, Dtk, RSE, Sky, Tif

GeneID: 7301

Research Use Only