Product Description

UB2L6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10428-50, ES10428-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: UB2L6

Specificity: UB2L6 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Present in natural killer cells (at protein level),

Observed Band (KD): 16kD

Fields: Ubiquitin mediated proteolysis, Parkinson disease, Pathways of neurodegeneration - multiple diseases

Function: Catalytic Activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
Induction: By interferon beta
Pathway: Protein modification, protein ubiquitination
Similarity: Belongs to the ubiquitin-conjugating enzyme family
Subunit: Interacts with RNF19A, RNF19B and RNF144B
Tissue Specificity: Present in natural killer cells (at protein level)

Subcellular Location: nucleoplasm, cytosol,

Storage and Stability: -20°C/1 year

Gene Name: UBE2L6 UBCH8

Protein Name: Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 6.3.2.19) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)

Mouse SwissProt Number: Q9QZU9

Rat SwissProt Number: Q4V8J2

Research Use Only