Product Description

UBE2V1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8126-50, BS8126-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Uev1A, also designated Uev1, UBE2V1 for Ubiquitin-conjugating enzyme E2 variant 1 and CROC1, shows sequence similarity to other ubiquitin-conjugating enzymes, but lacks the conserved cysteine residue critical for their catalytic activity . Therefore, Uev1A does not have ubiquitin-conjugating activity in vitro . However, constitutive expression of exogenous Uev1A in colon carcinoma cells inhibits their capacity to differentiate upon confluence. Studies on recombinant Uev1A show that it localizes to the nucleus, excluding the nucleolar regions . Uev1A functions with TRAF6, a RING domain protein, to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 of ubiquitin . The gene encoding Uev1A maps to human chromosome 20q13.2 .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, CROC-1, TRAF6-regμlated IKK activator 1 beta Uev1A, UBE2V1, CROC1, UBE2V, UEV1, P/OKcl.19

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human UBE2V1.

Dilution: WB 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: UBE2V1 polyclonal antibody detects endogenous levels of UBE2V1 protein.

Molecular Weight: ~ 16 kDa

Pathway: Ubiquitin Proteasome, Toll-like Receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13404

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only