uMtCK Monoclonal Antibody - BT-MCA1268

uMtCK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1268-50, BT-MCA1268-100

Citations, Manuals and MSDS Available upon request.

Background: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase| this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mi

Research Areas: Signal transduction; Metabolism; Cancer; Cell biology

Target Protein: CKMT1A

Applications: WB

Reactivity: Human,Mouse,Rat,Dog,Pig,Rabbit

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Creatine kinase U-type mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P12532; Mouse: P30275; Rat: P25809

Synonyms: CKMT1A; CKMT; CKMT1B; CKMT; Creatine kinase U-type; mitochondrial; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK

GeneID: Human: 1159; 548596; Mouse: 12716

Research Use Only