UNC5D Polyclonal Antibody - BT-AP15364

UNC5D Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15364-20, BT-AP15364-50, BT-AP15364-100

Citations, Manuals and MSDS Available upon request.

Background: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,Belongs to the unc-5 family.,Contains 1 death domain.,Contains 1 Ig-like (immunoglobulin-like) domain.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 ZU5 domain.,Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC.,

Research Areas: Neuroscience; Cardiovascular

Target Protein: UNC5D

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Netrin receptor UNC5D

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q6UXZ4; Mouse: Q8K1S2

Synonyms: Netrin receptor UNC5D;Protein unc-5 homolog 4;Protein unc-5 homolog D

GeneID: Human: 137970

Research Use Only