uPA Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA35916-50, RA35916-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: plasminogen activator, urokinase (PLAU) Homo sapiens This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: IHC-p, IF (paraffin section), ELISA Alternate Names: PLAU, Urokinase-type plasminogen activator, U-plasminogen activator, uPA Clonality: Polyclonal Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Storage: -20°C/1 year Human Gene ID: 5328 Human SwissProt Number: P00749 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only