uPA Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA35916-50, RA35916-100 Citations, Manuals and MSDS Available upon request. Background: plasminogen activator, urokinase (PLAU) Homo sapiens This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA) . HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA) . This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Alternative Names: PLAU; Urokinase-type plasminogen activator; U-plasminogen activator; uPA Applications: IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 5328 SWISS: P00749 Source: Rabbit Research Use Only