Uroplakin 3a Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB66034-50, MB66034-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during bladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, canine, porcine and ovine. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regμlated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a usefμl marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response. Category: Primary Antibody Reactivity: Human Host: Mouse Applications: IHC Alternate Names: UPK3, Uroplakin-3a, UP3a, Uroplakin III, UPIII Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Uroplakin 3a. The exact sequence is proprietary. Dilution: IHC (1/100 - 1/300) Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: Recognizes endogenous levels of Uroplakin 3a protein. Molecular Weight: ~ 30 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: O75631 Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide. Research Use Only