Product Description

VAMP1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11207-50, ES11207-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 30-110

Isotype: IgG

Target: VAMP1

Specificity: VAMP1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Nervous system, skeletal muscle and adipose tissue,

Observed Band (KD): 12kD

Fields: SNARE interactions in vesicular transport

Function: Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane
Similarity: Belongs to the synaptobrevin family
Similarity: Contains 1 v-SNARE coiled-coil homology domain
Subunit: Interacts with VAPA and VAPB
Tissue Specificity: Nervous system, skeletal muscle and adipose tissue

Subcellular Location: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Single-pass type IV membrane protein Cell junction, synapse, synaptosome, [Isoform 2]: Cytoplasmic vesicle membrane, Single-pass type IV membrane protein Cell junction, synapse, synaptosome, [Isoform 3]: Mitochondrion outer membrane, Single-pass type IV membrane protein

Storage and Stability: -20°C/1 year

Gene Name: VAMP1 SYB1

Protein Name: Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)

Mouse SwissProt Number: Q62442

Rat SwissProt Number: Q63666

Research Use Only