VAV1 Monoclonal Antibody - BT-MCA2621

VAV1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2621-50, BT-MCA2621-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Research Areas: Signal Transduction

Target Protein: VAV1

Applications: WB, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2E11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: VAV1

Immunogen: Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 98.3kDa

UniProt Accession: P15498

Synonyms: VAV

GeneID: 7409

Research Use Only