Product Description

VAV1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66894-50, MB66894-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Vav proteins belong to the Dbl family of guanine nucleotide exchange factors for Rho/Rac small GTPases. The three identified mammalian Vav proteins differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regμlating actin cytoskeleton organization . Phosphorylation stimμlates the GEF activity of Vav protein towards Rho/Rac .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: VAV, Proto-oncogene vav

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human VAV1. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of VAV1 protein.

Molecular Weight: ~ 94 kDa

Pathway: Regμlation of Actin Dynamics, T cell receptor signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P15498

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only