Vinculin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14193-20, A14193-100
Citations, Manuals and MSDS Available upon request.
Background: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 124kDa
Observed Molecular Weight: 124kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 7414
SWISS: P18206
Alternate Names: MV; MVCL; CMD1W; CMH15; HEL114; Vinculin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Actins, Cardiovascular, Heart, Contractility, Cardiac arrhythmias.
NCBI Alias: VCL
Research Use Only