WDR5 Monoclonal Antibody - BT-MCA4591

WDR5 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4591-50, BT-MCA4591-100

Citations, Manuals and MSDS Available upon request.

Background: WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.

Research Areas: Epigenetics and nuclear signaling

Target Protein: WDR5

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7B11

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: WDR5

Immunogen: Purified recombinant fragment of human WDR5 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 36.6kDa

UniProt Accession: P61964

Synonyms: SWD3, BIG-3, WDR5

GeneID: 11091

Research Use Only