WDR79 Monoclonal Antibody - BT-MCA1300

WDR79 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1300-50, BT-MCA1300-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.

Research Areas: Cell biology

Target Protein: WRAP53

Applications: WB

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Telomerase Cajal body protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9BUR4; Mouse: Q8VC51; Rat: Q5XII5

Synonyms: WRAP53; TCAB1; WDR79; Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53

GeneID: Human: 55135; Mouse: 216853; Rat: 287432

Research Use Only