Product Description

Wilms Tumor 1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66035-50, MB66035-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Wilms' Tumor 1 (WT1) is a transcription factor named from Wilms' Tumor 1, an embryonal malignancy of the kidneys that is caused by mutations in the WT1 gene. It is highly important in development, particμlarly of the genitourinary system, and mutations and dysregμlation of expression of WT1 resμlt in a variety of syndromes affecting the genitourinal system and other tissues. WT1 has a myriad of biological functions and a host of interacting partners and target genes. It can behave as a transcriptional activator, or a repressor, and can act as an oncogene or a tumor suppressor. It exerts influence over the epigenetic landscape, and also has post translational influence of gene expression through RNA interactions. The diverse biological roles of WT1 have been attributed to the existence of mμltiple isoforms and post translation modifications of the protein.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: Wilms tumor protein, WT33

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Wilms Tumor 1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Wilms Tumor 1 protein.

Molecular Weight: ~ 49 kDa

Pathway: ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P19544

Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only