WT1 Monoclonal Antibody - BT-MCA3617

WT1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3617-50, BT-MCA3617-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Research Areas: Epigenetics and nuclear signaling, Developmental biology, Cancer, Tags and cell markers

Target Protein: WT1

Applications: WB, IHC, ICC, FCM

Clonality: Monoclonal

Clone ID: 7F9E8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: WT1

Immunogen: Purified recombinant fragment of human WT1 (AA: 1-181) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 49.2kDa

UniProt Accession: P19544

Synonyms: GUD, AWT1, WAGR, WT33, NPHS4, WIT-2

GeneID: 7490

Research Use Only