XIAP Monoclonal Antibody - BT-MCA3866

XIAP Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3866-50, BT-MCA3866-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

Research Areas: Cell Biology

Target Protein: XIAP

Applications: FCM

Clonality: Monoclonal

Clone ID: 4C12G10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: XIAP

Immunogen: Purified recombinant fragment of human XIAP (AA: 1-268) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 56.7kDa

UniProt Accession: P98170

Synonyms: API3, ILP1, MIHA, XLP2, BIRC4, IAP-3, hIAP3, hIAP-3

GeneID: 331

Research Use Only