XPG Polyclonal Antibody - RA36230

XPG Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA36230-50, RA36230-100 Citations, Manuals and MSDS Available upon request. Background: ERCC excision repair 5, endonuclease (ERCC5) Homo sapiens This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. Alternative Names: ERCC5; ERCM2; XPG; XPGC; DNA repair protein complementing XP-G cells; DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein Applications: WB; IHC-p; IF/ICC; ELISA Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 2073 Protein MW (KDa): 130 SWISS: P28715 Source: Rabbit Research Use Only