XPG Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA36230-50, RA36230-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: ERCC excision repair 5, endonuclease (ERCC5) Homo sapiens This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, IHC-p, IF/ICC, ELISA Alternate Names: ERCC5, ERCM2, XPG, XPGC, DNA repair protein complementing XP-G cells, DNA excision repair protein ERCC-5, Xeroderma pigmentosum group G-complementing protein Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. Molecular Weight: 130 Protein Molecular Weight (kDa): 130 Storage: -20°C/1 year Human Gene ID: 2073 Human SwissProt Number: P28715 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only