ZAP70 Monoclonal Antibody - BT-MCA2633

ZAP70 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2633-50, BT-MCA2633-100

Citations, Manuals and MSDS Available upon request.

Background: ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Research Areas: Immunology

Target Protein: ZAP70

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3D2A4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ZAP70

Immunogen: Purified recombinant fragment of human ZAP70 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 70kDa

UniProt Accession: P43403

Synonyms: SRK, STD, TZK

GeneID: 7535

Research Use Only