Zic1/2/3 (D348) Polyclonal Antibody-BS2455

Zic1/2/3 (D348) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2455-50, BS2455-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15915/O95409/O60481

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: Zic1 encodes a zinc finger protein expressed in the developing or matured central nervous system in a highly restricted manner. Zic is expressed in granule cells that make synaptic contact with Purkinje cells. Zic1 is a gene critical to cerebellar pattern formation. The expression of Zic genes is first detected at gastrulation and at neurulation, becoming restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm. The Zic1 gene has been mapped to chromosome 9 in mouse. The 5' flanking region of the Zic1 gene contains a region-specific enhancer determined to be essential in in-vivo and in-vitro deletion analysis. The temporal profile of mRNA expression differs for each of the Zic gene products. The Drosophila odd-paired gene is highly homologous to the Zic gene family. Zic2 and Zic3 are highly similar genes. Zic2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Zic1/2/3 (D348) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 51 kDa

Specificity: Zic1/2/3 (D348) polyclonal antibody detects endogenous levels of Zic1/2/3 protein.

Alternative Name: Zinc finger protein ZIC 1; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; ZIC1; ZIC; ZNF201; Zinc finger protein ZIC 2; Zinc finger protein of the cerebellum 2; ZIC2; Zinc finger protein ZIC 3; Zinc finger protein 203; Zinc finger protein of the cerebellum 3; ZIC3; ZNF203

Immunogen: Synthetic peptide, corresponding to amino acids 318-366 of Human Zic1.

Conjugate: Unconjugated

Modification: Unmodified