Product Description

ZIP4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6734-50, ES6734-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: SLC39A4, ZIP4, Zinc transporter ZIP4, Solute carrier family 39 member 4, Zrt- and Irt-like protein 4, ZIP-4

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human SLC39A4. AA range:431-480

Isotype: IgG

Target: ZIP4

Specificity: ZIP4 Polyclonal Antibody detects endogenous levels of ZIP4 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum,

Observed Band (KD): 68kD

Fields: Mineral absorption, Alzheimer disease, Parkinson disease

Function: Disease: Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ) [MIM: 201100]. AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal
Function: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability
Similarity: Belongs to the ZIP transporter (TC 2.A.5) family
Subcellular Location: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability
Tissue Specificity: Highly expressed in kidney, small intestine, stomach, colon

Subcellular Location: Cell membrane, Multi-pass membrane protein Recycling endosome membrane, Multi-pass membrane protein Colocalized with TFRC in the recycling endosomes Cycles between endosomal compartments and the plasma membrane in response to zinc availability

Storage and Stability: -20°C/1 year

Gene Name: SLC39A4

Protein Name: Zinc transporter ZIP4

Mouse SwissProt Number: Q78IQ7

Research Use Only