Product Description

α-SMA Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS70000-50, BS70000-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P62736

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:1000~1:2000

Background: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of α-SMA pAb at 1:1000 dilution
Lane 1:MCF-7 whole cell lysate (40ug)
Lane 2:HepG2 whole cell lysate (40ug)

Bioworld Molecular Weight: ~ 45 kDa

Specificity: α-SMA polyclonal antibody detects endogenous levels of α-SMA protein.

Alternative Name: ACTA2; AAT6; ACTSA; MYMY5; Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; alpha-SMA; a-SMA; aSMA; SMA-alpha

Immunogen: Synthetic peptide, corresponding to Human α-SMA.

Conjugate: Unconjugated

Modification: Unmodified