α-Synuclein Rabbit PolymAb® - A22598PM

α-Synuclein Rabbit PolymAb®

Sizes: 20μL, 100μL

Catalogue Numbers: A22598PM-20, A22598PM-100

Citations, Manuals and MSDS Available upon request.

Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Category: Monoclonal Antibodies

Applications: WB, IHC-P, IF/ICC, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 14kDa

Observed Molecular Weight: 18kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 6622

SWISS: P37840

Alternate Names: PD1; NACP; PARK1; PARK4

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:1000-1:5000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Protein phosphorylation, Cell Biology Developmental Biology, Apoptosis, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Dopamine Signaling in Parkinson's Disease, Neurodegenerative Diseases Ma

NCBI Alias: SNCA

Research Use Only