11β-HSD1 rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES4290-50, ES4290-100
Citations, Manuals and MSDS Available upon request.
Background: hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011],
Alternate Name: HSD11B1; HSD11; HSD11L; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1
Source: Rabbit
Applications: WB; IHC; IF; ELISA
Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Reactivity: Human; Mouse; Rat
Immunogen: Synthesized peptide derived from 11β-HSD1 . at AA range: internal
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 35kD
Human Gene ID: 3290
Human SWISS Prot NO: P28845
Subcellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Research Use Only