Product Description

1A68 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18548-50, ES18548-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human 1A68 AA range: 1-51

Isotype: IgG

Target: 1A68

Specificity: This antibody detects endogenous levels of 1A68 at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 40kD

Function: Function: Involved in the presentation of foreign antigens to the immune system
polymorphism: The following alleles of A-1 are known: A*0101, A*0102, A*0103, A*0106 and A*0107. The sequence shown is that of A*0101
polymorphism: The following alleles of A-11 are known: A*1101 (A-11E), A*1102 (A-11K), A*1103, A*1104, A*1105 and A*1107. The sequence shown is that of A*1101
polymorphism: The following alleles of A-2 are known: A*0201, A*0202, A*0203, A*0204, A*0205, A*0206 (A2.4A), A*0207, A*0208, A*0209, A*0210, A*0211 (A2.5), A*0212, A*0213 (A*02SLU), A*0216, A*0217, A*0218 (A2K), A*0219, A*0220, A*0221, A*0231, A*0234 (A*AAT), A*0235, A*0236 and A*0237. The sequence shown is that of A*0201
polymorphism: The following alleles of A-23 are known: A*2301, A*2302, A*2303, A*2304 and A*2305. The sequence shown is that of A*2301
polymorphism: The following alleles of A-24 are known: A*2401, A*240

Subcellular Location: Golgi membrane, endoplasmic reticulum, Golgi apparatus, Golgi medial cisterna, plasma membrane, integral component of plasma membrane, cell surface, ER to Golgi transport vesicle membrane, membrane, integral component of membrane,

Storage and Stability: -20°C/1 year

Gene Name: HLA-A HLAA

Protein Name: 1A68

Research Use Only