Product Description

ABCB9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18513-50, ES18513-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ABCB9 AA range: 224-274

Isotype: IgG

Target: ABCB9

Specificity: This antibody detects endogenous levels of ABCB9 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.312% sodium azide.

Expression: Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid, Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages,

Observed Band (KD): 85kD

Fields: ABC transporters, Lysosome

Function: Function: May function as a peptide transporter
Similarity: Belongs to the ABC transporter family
Similarity: Belongs to the ABC transporter family. MHC peptide exporter (TC 3.A.1.209) subfamily
Similarity: Contains 1 ABC transmembrane type-1 domain
Similarity: Contains 1 ABC transporter domain
Subunit: Homodimer or heterodimer
Tissue Specificity: Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid

Subcellular Location: Lysosome membrane, Multi-pass membrane protein May be located in membrane rafts Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments (PubMed:30877195)

Storage and Stability: -20°C/1 year

Gene Name: ABCB9 KIAA1520

Protein Name: ABCB9

Mouse Gene ID: 56325

Mouse SwissProt Number: Q9JJ59

Rat Gene ID: 63886

Rat SwissProt Number: Q9QYJ4

Research Use Only