ABflo® 488 Rabbit anti-Human CD100/SEMA4D Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24405-100, A24405-200, A24405-500
Citations, Manuals and MSDS Available upon request.
Background: Plexin-B1 is related to axon guidance in the central nervous system. The Sema4D function is also widely detected in the immune system and was found to be the first semaphorin expressed on the surface of many types of immune cells. In the immune system, CD72 is a low-affinity receptor for Sema4D, and studies have shown that Sema4D can not only regulate T cell activation, but also participate in the regulation of B cell survival and differentiation. In the immune system, soluble fragments containing extracellular domains produced by proteolytic cleavage can regulate many physiological functions of Sema4D. Sema4D is also associated with tumorigenesis because studies have confirmed that it is overexpressed in various types of solid tumor cells. To some extent, the role of Sema4D in tumorigenesis is related to its ability to cause tumor angiogenesis, cell invasion, and immunosuppression by enhancing bone marrow-derived suppressor cell function.
Category: Monoclonal Antibodies
Application: IF/ICC, FC
Cross Reactivity: Human
Protein Weight: 82kDa/96kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 10507
SWISS: Q92854
Alternate Names: SEMA4D; C9orf164; CD100; M-sema-G; SEMAJ; coll-4; semaphorin-4D
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: IF/ICC,1:50 - 1:200|FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Cell Biology and Developmental Biology, Apoptosis, Immunology and Inflammation, CD markers, Neuroscience, Cell Type Marker
NCBI Alias: SEMA4D
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC63157
Research Use Only